Project 1: Ischemic Stroke Biomarkers
Strokes are the leading cause of severe long-term disability and the third leading cause of death in the United States. According to the World Health Organization, there are 700,000 strokes in the U.S. annually and 21 million worldwide.
Prof. Dambinova has identified novel biomarkers emitted by the brain into the bloodstream, where they can be detected. These markers, the NR2 peptide and the NR2 antibody, greatly improve the diagnostic certainty of identifying ischemic stroke vs non-stroke disorders at ED. Ischemia is a restriction in blood supply, generally due to factors in the blood vessels with resultant damage or dysfunction of affected tissue. The research of clinical utility of NR2 biomarkers to assess acute and chronic ischemic strokes is performing in collaboration with Stanford University (Dr. Albers) and DeKalb Medical (Dr. Weissman).
Glutamate receptors degradation underlying cerebral ischemia due to thrombotic/embolic processes in the brain. |
References:
Gusev, E.I., Skvortsova, V.I., Dambinova, S.A., Raevskiy, K.S., Alekseev, A.A., Bashkatova, V.G., Kovalenko, A.V., Kudrin, V.S., and Yakovleva, E.V. Neuroprotective effects of glycine for therapy of acute ischemic stroke. Cerebrovasc.Dis. 10: 49-60, 2000
Dambinova, S.A., Khounteev, G.A., Skorometz, A.A. Multiple panel of biomarkers for TIA/Stroke evaluation. Stroke 33:1181-1182, 2002
Dambinova, S.A., Khounteev, G.A., Izykenova, G.A., Zavolokov, I.G., Ilyukhina, A.Yu., Skoromets, A.A. Blood test detecting autoantibodies to NMDA neuroreceptors for evaluation of patients with transient ischemic attack and stroke. Clin Chem. 49:1752-1762, 2003.
Bokesch, P.M., Izykenova, G.A., Justice, J.B., Easley, K., Dambinova, S.A. Predicting adverse neurological outcome before cardiac surgery using blood biomarkers. Stroke, 37 (6):1432-1436, 2006.
Christenson, R.H., Dambinova, S. Stroke. A look at emerging biochemical markers. Clin Lab News, 34:10-12, 2008
Dambinova, S.A. Biomarkers for transient ischaemic attack (TIA) and ischaemic stroke. Clin Lab Inter, 32:7-11, 2008
Skoromets, A.A., Dambinova, S.A., Djakonov, M.M., Granstrem, O.K., et al. Novel biomarkers for brain damage. Neuroimmunology7:18-23, 2009
Skoromets, A.A., Dambinova, S.A., Djakonov, M.M., Granstrem, O.K., et al. Biochemical markers in diagnostics of ischemic stroke. Intern. Neurol. J.5:15-20, 2009
Weissman JD, Khunteev GA, Heath R, Dambinova SA. NR2 antibodies: risk assessment of transient ischemic attack (TIA)/stroke in patients with history of isolated and multiple cerebrovascular events. J Neurol Sci. 300(1-2):97-102, 2011
Weissman JD, Khunteev GA, Dambinova SA. Biomarkers in acute stroke. MAG Journal,3:20-22, 2012.
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